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- Biology Olympiad
- Black Student Union
- Business Professionals of America
- Cadenza
- Chess Club
- CIC (Community Inclusion Club)
- Colors
- Cubing Club
- Debate and Speech
- Dongari
- Drama/Thespians
- Environmental Club
- F-Cubed: Fun for Fridays
- FCCLA (Family, Career, and Community Leaders of America)
- Fellowship of Christian Athletes
- Food For All (FFA)
- G! World
- Girls Who Code Club
- Global Health
- Grapevine (Literary Magazine)
- Hip Hop Club
- HOSA-Future Health Professionals
- Houses Into Homes West
- Improv Club
- Intramurals
- Investing Club
- Iowa City Metallic Wings (Ultimate Frisbee)
- K-Pop Dance Team
- Korean Culture Club
- Latinx Student Union - Unidos
- Maker's Studio
- Mock Trial
- Model UN Club
- Mu Alpha Theta (Math Club)
- Muslim Student Association
- NHS (National Honor Society)
- OESTEM (Overcoming Exclusion in STEM)
- Pep Club
- Philosophy Club
- Physics Team
- Red Cross Club
- Robotics Club (FRC)
- Robotics Club (FTC) (Trobotix)
- Rocketry Club
- Science Olympiad Club
- SEA (Students for Environmental Action)
- SPIT (Student Produced Innovative Theatre)
- Spoken Word Club
- SSG (Sudanese Student Group)
- Sustainable Fashion Club
- Table Top Gaming Club
- TALK- Mental Health Club
- These Books Are Lit Book Group
- TSA Cyber Security (Technology Student Association)
- TSA JETS (Junior Engineering Technical Society), Technology Student Association
- UNICEF Club
- Walk-It-Out
- Weightlifting Club
- West High Drone Racing
- World Language & Culture Club
- WSG - West Student Government
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